Homeostasis : JUNE 2012 / VARIANT 41 / Q10 B
HOMEOSTASIS JUNE 2012 / VARIANT 41 / Q10 B Describe the mechanisms involved in reabsorption in the proximal convoluted tubule and describe how the epithelial cells of the proximal convoluted tubule are adapted to carry out this process. [9] This questions demands a great detail to be written. A good approach of writing the answer would be: The proximal convoluted tubule is the main site of selective reabsorption in the kidney. It reabsorbs approximately 100 % small proteins, glucose and amino acids. The mechanism of reabsorption of glucose is as follows. The Na+- K+ pump on the basolateral membrane actively pumps 3Na+ outside and 2K+ into the cells against the concentration gradient. This creates a concentration gradient to allow Na+ to move into the cell from the luminal fluid. Na+ are co-transported into the PCT cells together with glucose via the Na+- glucose co-transporter. This mechanism of glucose reabsorption into the PCT cells is known as secondary active transpo...